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Disinfectant and Antiseptics

Avid Organics provides Disinfectants and Antiseptics which dissolves in hot n-Butanol and Mineral acid; Very slightly soluble in Methanol; Practically in soluble in water and can be used in cosmetics and many more.

Chlorhexidine Base

It is considered as a sub product which provides best solutions. It is basically White or almost white powder & IR spectrum of the test sample should be concordant with that of Chlorhexidine working standard values

General Info :

CAS Number Molecular Formula Molecular Weight
55-56-1 C22H30Cl2N10 505.46 gm/mol

Sales Specification :

Avichlorhex - B (Chlorhexidine Base)

Parameter Avichlorhex - B Specification Reference
Description White or almost white powder In-house
Solubility It dissolves in hot n-Butanol and Mineral acid; Very slightly soluble in Methanol; Practically in soluble in water In-house
Identification
A) IR A) IR spectrum of the test sample should be concordant with that of Chlorhexidine working standard EP
B) Melting Range B) Between 132°C -136°C EP
C) Color test C) A deep red color produced In-House
Loss on drying Not More Than 1.0 % w/w EP
Sulphated Ash Not More Than 0.1 % w/w EP
P-Chloroaniline Not More Than 500 ppm EP
Assay 98 % to 102 % on dried basis In-house
Related Substance (by HPLC)
Chlorhexidine oxazinone analog Not more than 0.2 % USP
Specified unidentified impurity-1 Not more than 0.2 % USP
Chlorhexidine Amine Not more than 0.3 % USP
Chlorhexidine guanidine Not more than 1.0 % USP
Chlorhexidine urea Not more than 0.2 % USP
p-Chlorophenyl urea Not more than 0.2 % USP
Chlorhexidine nitrile Not more than 0.4 % USP
Chlorhexidine dimer Not more than 0.5 % USP
o- Chlorhexidine and specified unidentified impurity-2 Not more than 0.4 % USP
Chlorhexidine glucityl triazine Not more than 0.4 % USP
Oxochlorhexidine Not more than 0.4 % USP
Any individual Unspecified imp. Not more than 0.10 % USP
Total impurities Not more than 1.5 % USP
Additional Test
Residual Solvents
1) Methanol
2) n-Butanol
3) Benzene
NMT 3000 ppm
NMT 5000 ppm
NMT 2 ppm
IH

Market Applications :

  • Chlorhexidine is used in disinfectants (disinfection of the skin and hands), cosmetics (additive to creams, toothpaste, deodorants, and antiperspirants), and pharmaceutical products (preservative in eye drops, active substance in wound dressings and antiseptic mouthwashes).

Disinfectant and AntisepticsChlorhexidine Digluconate

Avid Organics provides Chlorhexidine Digluconate As the test sample should be concordant with that of Chlorhexidine Digluconate working standard & it is aAlmost colourless or pale yellowish liquid.

Sales Specification :

Avichlorhex- G (Chlorhexidine Digluconate)

Parameter Avichlorhex- G Specification (USP) Avichlorhex- G Specification (EP) Avichlorhex- G Specification (IP) Avichlorhex- G Specification (BP)
Description Almost colourless or pale yellowish liquid. Almost colourless or pale yellowish liquid. Almost colourless or pale yellowish liquid. Almost colourless or pale yellowish liquid.
Solubility in water Miscible. Miscible. Miscible. Miscible.
Identification
A)I.R. IR spectrum of the test sample should be concordant with that of Chlorhexidine Digluconate working standard IR spectrum of the test sample should be concordant with that of Chlorhexidine Digluconate working standard IR spectrum of the test sample should be concordant with that of Chlorhexidine Digluconate working standard IR spectrum of the test sample should be concordant with that of Chlorhexidine Digluconate working standard
B) Relative Density 1.06 – 1.07 1.06 – 1.07 1.06 – 1.07 1.06 – 1.07
C) pH (5% v/v Solution) 5.5 to 7.0. 5.5 to 7.0. 5.5 to 7.0. 5.5 to 7.0.
Loss on drying Maximum 1.0 % w/w. Maximum 1.0 % w/w Maximum 1.0 % w/w Maximum 1.0 % w/w
Sulphated Ash Maximum 0.1 % w/w Maximum 0.1 % w/w Maximum 0.1 % w/w Maximum 0.1 % w/w
Related substance NMT 3% NMT 3% NMT 3% NMT 3%
Chlorhexidine oxazinone analogue NMT 0.2% As per EP As per IP As per BP
Impurity N NMT 1.0%
Specified unidentified impurity 1 NMT 0.2% Impurity H NMT 0.50%
Chlorhexidine amine NMT 0.3% Impurity A NMT 0.40%
Chlorhexidine guanidine NMT 1.0% Impurity J NMT 0.40%
Chlorhexidine urea NMT 02% Impurity K NMT 0.40%
ρ-Clorophenyl urea NMT 0.2% Sum of Impurities I&O NMT 0.40%
Chlorhexidine nitrile NMT 0.4% Impurity G NMT 0.30%
ο-Chlorhexidine and specified unidentified impurity 2 NMT 0.2% Impurity B NMT 0.20%
Chlorhexidine glucityl triazine NMT 0.2% Impurity F NMT 0.20%
Oxochlorhexidine NMT 0.2% Impurity L NMT 0.20%
Any individual unspecified impurity NMT 0.2% Impurity Q NMT 0.20%
Unspecified
Impurities NMT 0.10%
Limit of p-Chloroaniline NMT 500 ppm NMT 100 ppm
Total impurities NMT 3.0% Total impurities NMT 3.0% Total impurities NMT 3.0% Total impurities NMT 3.0% Total impurities NMT 3.0%
Assay (by potentiometrically) Chlorhexidine Digluconate solution is an aqueous solution which contains NLT 190 g/L and NMT 210 g/L 1,1’-Hexamethylene-[5-(4-Chlorophenyl)-Biguanide]di(D-Digluconate) Chlorhexidine Digluconate solution is an aqueous solution which contains NLT 190 g/L and NMT 210 g/L 1,1’-Hexamethylene-[5-(4-Chlorophenyl)-Biguanide]di(D-Digluconate) Chlorhexidine Digluconate solution is an aqueous solution which contains NLT 190 g/L and NMT 210 g/L 1,1’-Hexamethylene-[5-(4-Chlorophenyl)-Biguanide]di(D-Digluconate) Chlorhexidine Digluconate solution is an aqueous solution which contains NLT 190 g/L and NMT 210 g/L 1,1’-Hexamethylene-[5-(4-Chlorophenyl)-Biguanide]di(D-Digluconate)

Market Applications :



Topical use

  • Surgical scrub and antiseptic hand rinse for healthcare personnel.
  • Skin cleanser for preoperative skin preparation, skin wound and general skin cleanser for patients.

Oral use

  • Oral rinse: 0.12% Antibacterial dental rinse for gingivitis treatment
  • Periodontal chip: Adjunctive therapy to reduce pocket depth in patients with periodontitis.

Veterinary use

  • Effective protection against Mastitis by cows.
  • Used in the general dairy hygiene of milk producing animals.
  • Typical concentration as antiseptic is 0.5 – 4% of Chlorhexidine Di Gluconate.

Disinfectant and AntisepticsChlorhexidine Diacetate BP/EP/USP

Avid Organics provides Chlorhexidine Diacetate BP/EP/USP Which is a white to off white powder compiles with spectrum of different substance with best values


Disinfectant and AntisepticsChlorhexidine Dihydrochloride BP/EP/USP

Avid Organics provides Chlorhexidine Dihydrochloride Diacetate BP/EP/USP which is White or almost white crystalline powder complies with the IR spectrum of reference standard of chlorhexidine Diacetate. Used as a preservative in creams, ointments and gels.



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